Neuropeptide W-23(human)

Research use only, not for human use.

Neuropeptide W-23(human) is an endogenous ligand for NPBW1 and NPBW2. NPW-23 increases the ICa,L in transfected human embryonic kidney 293 cells and VSMCs via GPR7. NPW-23 increases the expression of pan phospho-PKC, intracellular diacylglycerol level, and the second messenger catalyzed by PLC.

Neuropeptide W-23(human) is an endogenous ligand for NPBW1 and NPBW2. NPW-23 increases the ICa,L in transfected human embryonic kidney 293 cells and VSMCs via GPR7. NPW-23 increases the expression of pan phospho-PKC, intracellular diacylglycerol level, and the second messenger catalyzed by PLC.NPW-23 increases pressure-induced vasotone of the rat mesenteric arteries. Importantly, the expression of NPW is decreased in the hypertensive rats. NPW-23 (0.3 nmol, 1.0 nmol, and 3.0 nmol) induces significant increases in mean arterial pressure (MAP) in conscious, freely moving male rats. Rats that receive either 1.0 or 3.0 nmol NPW-23 demonstrate a significant increase in total activity, ambulatory activity, and duration of stereotypy. NPW-23 fails to elevate MAP in rats pretreated with phentolamine. NPW-23-induced increases in total activity, ambulatory activity, and duration of stereotypy are reduced significantly by pretreatment with the orexin type 1 receptor (OX1R) antagonist, SB-408124.

NPW-23

Others

Other Targets

Others

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383415-79-0

2583.02

C120H184N34O28S

>98% (HPLC)

H2O

Oc1ccc(cc1)C[C@H](NC(=O)[C@@H](N)Cc2cnc3ccccc23)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](Cc4cncn4)C(=O)N[C@@H](C(C)C)C(=O)N[C@@H](C)C(=O)N[C@@H](CO)C(=O)N7CCC[C@H]7C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](Cc5ccc(O)cc5)C(=O)N[C@@H](Cc6cncn6)C(=O)N[C@@H]([C@H](O)C)C(=O)N[C@H](C(=O)NCC(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](C)C(=O)N[C@@H](C)C(=O)NCC(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCSC)C(=O)NCC(=O)N[C@@H](CC(C)C)C(=O)O)C(C)C

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(-20℃)

With Ice Pack

≥ 2 years